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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-1
All Species:
18.48
Human Site:
S138
Identified Species:
40.67
UniProt:
P43699
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43699
NP_001073136.1
371
38596
S138
P
A
S
G
M
N
M
S
G
M
G
G
L
G
S
Chimpanzee
Pan troglodytes
XP_509911
401
41649
S168
P
A
S
G
M
N
M
S
G
M
G
G
L
G
S
Rhesus Macaque
Macaca mulatta
XP_001089890
371
38509
S138
P
A
S
G
M
N
M
S
G
M
G
G
L
G
S
Dog
Lupus familis
XP_849082
233
24205
F26
A
A
T
P
V
S
R
F
M
G
P
S
A
G
V
Cat
Felis silvestris
Mouse
Mus musculus
P50220
372
38552
S138
P
A
S
G
M
N
M
S
G
M
G
G
L
G
S
Rat
Rattus norvegicus
P23441
372
38536
S138
P
A
S
G
M
N
M
S
G
M
G
G
L
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
S87
E
M
D
T
A
K
D
S
K
A
D
K
K
E
L
Frog
Xenopus laevis
P42587
196
22791
Zebra Danio
Brachydanio rerio
Q90481
269
30288
N62
V
Q
N
L
P
L
K
N
P
F
Y
D
N
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
R92
A
F
P
Y
G
P
G
R
L
P
G
N
Y
F
A
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
N144
M
N
M
N
M
N
M
N
M
N
M
S
T
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.7
99.1
40.7
N.A.
98.1
98.6
N.A.
N.A.
32
30.7
32.6
N.A.
N.A.
N.A.
26.6
38.4
Protein Similarity:
100
91.7
99.1
46.6
N.A.
98.1
98.6
N.A.
N.A.
43.4
40.4
43.4
N.A.
N.A.
N.A.
40.4
50.3
P-Site Identity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
6.6
0
0
N.A.
N.A.
N.A.
6.6
26.6
P-Site Similarity:
100
100
100
33.3
N.A.
100
100
N.A.
N.A.
6.6
0
13.3
N.A.
N.A.
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
55
0
0
10
0
0
0
0
10
0
0
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
0
10
0
0
0
10
10
0
0
10
% D
% Glu:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
10
0
0
0
0
0
10
0
10
0
0
0
10
0
% F
% Gly:
0
0
0
46
10
0
10
0
46
10
55
46
0
55
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
10
0
10
0
0
10
10
0
0
% K
% Leu:
0
0
0
10
0
10
0
0
10
0
0
0
46
10
10
% L
% Met:
10
10
10
0
55
0
55
0
19
46
10
0
0
0
0
% M
% Asn:
0
10
10
10
0
55
0
19
0
10
0
10
10
0
0
% N
% Pro:
46
0
10
10
10
10
0
0
10
10
10
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% R
% Ser:
0
0
46
0
0
10
0
55
0
0
0
19
0
10
55
% S
% Thr:
0
0
10
10
0
0
0
0
0
0
0
0
10
0
0
% T
% Val:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _